When Reign starts hunting Ruby, Supergirl and Alex work together to keep her safe. Supergirl and J’onn look to Sam’s mother for advice on how to stop Reign and come…

Supergirl and Imra have different ideas on how to stop the third Worldkiller, Pestilence. However, when both Alex and Winn are seriously injured by Pestilence, Supergirl and Imra team up…

As Reign continues to terrorize the city, Supergirl teams up with Saturn Girl, and the two recruit Supergirl’s former enemies, Livewire and Psi, to form a team for a mission…